产品概述
产品性能
免疫原
产品应用
研究背景
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010],function:Regulator of TNF and IL-1 induced NF-kappa-B activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the UPF0396 family.,
研究领域
Transcription; Other factors; Epigenetics and Nuclear Signaling; Nuclear Signaling Pathways; NFkB pathway; Stem Cells; Signaling Pathways; Notch Nuclear; NFkB Pathway; Immunology; Adaptive Immunity; T Cells; Non-CD; Signal Transduction
