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The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010],function:Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity.,induction:By ponisterone A in erythroleukemia cells.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subcellular location:Accumulation into PML nuclear bodies is mediated by PML.,subunit:Interacts via an N-terminal region with the RUNX1 Runt domain. Interacts via its C-terminus with PML; this interaction enhances ELF4 transactivation of the bovine lysozyme gene.,tissue specificity:Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.,
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