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PD‑1：免疫检查点分子程序性细胞死亡蛋白 1

PD‑1：免疫检查点分子程序性细胞死亡蛋白 1

PD‑1 诱导 T 细胞抑制可能存在两种机制。其一：细胞表面 PD‑1 可被 Lck 或 CD45 动态磷酸化/去磷酸化；与可溶性 PD‑1 配体结合并不改变这一动态平衡，但固定化 PD‑1 配体可把 PD‑1 募集到细胞‑细胞界面，在那里 CD45 被排除，缺乏 CD45 使 PD‑1 更易被 Lck 磷酸化；且 TCR/CD28 信号促进 Lck 活化，也有利于 PD‑1 磷酸化。其二：PD‑1 胞内域（ICD）可能采取一种自我保护免于磷酸化的构象；可溶性配体难以影响这种受抑制的 ICD 构象，而表面表达的 PD‑1 配体可把力传递给 PD‑1 并改变该构象，从而促进磷酸化。两种模型中，PD‑1 与 TCR 和/或 CD28 的共定位都是 PD‑1 抑制 T 细胞所必需；孤立的固定化 PD‑1 配体或可诱导 PD‑1 磷酸化，但未必造成 T 细胞抑制。

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一抗产品列表
靶点货号产品名称种属反应性应用
PD‑1AMM82044PD1 Mouse Monoclonal AntibodyHumanWB,ELISA,FC
CD45AMRe86788CD45 Rabbit Monoclonal AntibodyHuman,MouseWB,IHC,IP
CD28AMRe87395CD28 Rabbit Monoclonal AntibodyHuman,Mouse,RatWB,IHC,ICC/IF,IP
CD80AMM82267CD80 Mouse Monoclonal AntibodyHuman,Mouse,Rat,RabbitIHC,ELISA,FC
CD86AMRe83722CD86 Rabbit Monoclonal AntibodyHuman,Mouse,RatWB,IHC,ICC/IF,ICC,FC,IP
PD‑L1/CD274AMRe15922PD‑L1 (CD274) (5R18) Rabbit Monoclonal AntibodyHumanWB,IHC,ICC/IF,FC,IP
重组蛋白产品列表
靶点货号产品名称种属反应性表达系统
Mouse PD‑1PHM1274Recombinant Mouse PD‑1 (C‑6His)MouseHuman Cells
Human PD‑1PHH1277Recombinant Human PD‑1 (C‑6His)HumanHuman Cells
Mouse CD45PHM2289Recombinant Mouse CD45 (C‑6His)MouseHuman Cells
Human CD45PHH2332Recombinant Human CD45 (C‑6His)HumanHuman Cells
Mouse CD28PHM1612Recombinant Mouse CD28 (C‑Fc‑6His)MouseHuman Cells
Human/Cynomolgus CD28PHV2077Recombinant Human/Cynomolgus CD28 (N‑6His)Human/CynomolgusHuman Cells
Human B7‑1/CD80PHH0123Recombinant Human B7‑1 (C‑6His)HumanHuman Cells
Mouse B7‑1/CD80PHM1661Recombinant Mouse B7‑1 (C‑6His)MouseHuman Cells
Cynomolgus B7‑1/CD80PHV1662Recombinant Cynomolgus B7‑1 (C‑6His)CynomolgusHuman Cells
Rat B7‑1/CD80PHR1663Recombinant Rat B7‑1 (C‑6His)RatHuman Cells
Human B7‑2/CD86PHH0124Recombinant Human B7‑2 (C‑6His)HumanHuman Cells
Mouse B7‑2/CD86PHM1667Recombinant Mouse B7‑2 (C‑6His)MouseHuman Cells
Rat CD86PHR1668Recombinant Rat CD86 (C‑6His)RatHuman Cells
Human PD‑L1PHH0128Recombinant Human PD‑L1 (C‑6His)HumanHuman Cells
Mouse PD‑L1PHM1293Recombinant Mouse PD‑L1 (C‑6His)MouseHuman Cells
Rat PD‑L1PHR1896Recombinant Rat PD‑L1 (C‑6His)RatHuman Cells

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参考文献

  • Mechanical force regulates the inhibitory function of PD‑1. Chen H, et al. EMBO Rep. 2026. [PMID: 41741724]
  • In vitro reconstitution of T cell receptor‑mediated segregation of the CD45 phosphatase. Carbone CB, et al. Proc Natl Acad Sci U S A. 2017. [PMID: 29042512]
  • Self‑programmed dynamics of T cell receptor condensation. Chen H, et al. Proc Natl Acad Sci U S A. 2023. [PMID: 37399423]
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