产品概述
产品性能
免疫原
产品应用
研究背景
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.
研究领域
Signal Transduction; Cytoskeleton / ECM; Cytoskeleton; Microfilaments; Actin etc; Actin Assembly; Protein Phosphorylation; Ser / Thr Kinases; MAPK Pathway; Epigenetics and Nuclear Signaling; Cell cycle; Kinases/Phosphatases
