OLFM2 Rabbit Monoclonal Antibody-EnkiLife

OLFM2 Rabbit Monoclonal Antibody

规格：20μL 价格：￥680
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB,IHC-P
种属（Reactivity）：Human,Mouse
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：OLFM2 SKU: AMRe86567 Category: 兔单克隆抗体 Tags: Rabbit, Unconjugated, WB, IHC-P, Human, Mouse

说明书复制

产品概述

产品名称（Product Name）	OLFM2 Rabbit Monoclonal Antibody
描述（Description）	Rabbit Monoclonal antibody
宿主（Host）	Rabbit
应用（Application）	WB,IHC-P
种属反应性（Reactivity）	Human,Mouse

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
纯化方式（Purification）	Affinity Purification

免疫原

基因名（Gene Name）	OLFM2
别名（Alternative Names）	NOE2; OlfC; NOELIN2; NOELIN2_V1
基因ID（Gene ID）	93145
蛋白ID（SwissProt ID）	O95897

产品应用

稀释比（Dilution Ratio）	WB: 1:1000-1:5000 IHC-P: 1:100-1:200
蛋白分子量（Molecular Weight）	Calculated MW:51 kDa; Observed MW:49 kDa

研究背景

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).