| 产品名称 |
Recombinant Human HMGB1 (N-teminal) |
| 英文名称 |
HMGB1/High mobility group protein B1/HMG-1 |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human High Mobility Group Protein B1 is produced by our E.coli expression system and the target gene encoding Met1-Phe89 is expressed. |
| Accession |
P09429 |
| 表达宿主 |
E.coli |
| 种属 |
Human |
| 预测分子量 |
10.4 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 500mM NaCl, 0.5mMDTT, pH 7.9 . |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| High Mobility Group Protein B1; High Mobility Group Protein 1; HMG-1; HMGB1; HMG1 |
| 背景介绍 |
| High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
