Prolactin Receptor (2K9) Rabbit Monoclonal Antibody

Prolactin Receptor (2K9) Rabbit Monoclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB,IHC-P,ICC/IF,IF-P

种属(Reactivity):Human,Mouse,Rat
偶联物(Conjugate):Unconjugated
基因名(Gene Name):PRLR
SKU: AMRe16522 Category: 兔单克隆抗体 Tags: , , , , , , , , ,

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产品概述

产品名称(Product Name)

Prolactin Receptor (2K9) Rabbit Monoclonal Antibody

描述(Description)

Recombinant rabbit monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB,IHC,ICC/IF

种属反应性(Reactivity)

Human,Mouse,Rat

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式(Purification)

Affinity purification

 

免疫原

基因名(Gene Name)

PRLR

别名(Alternative Names)

CPRLP; HPRL; hPRL receptor; Lactogen receptor; MFAB; OPR; Pr-1; Pr-3; PRLR; Prolactin receptor a;

基因ID(Gene ID)

5618

蛋白ID(SwissProt ID)

P16471

 

产品应用

稀释比(Dilution Ratio)

WB 1:1000-1:5000,IHC 1:50-1:100,ICC/IF 1:100-1:200

蛋白分子量(Molecular Weight)

70kDa

 

研究背景

Activate multiple signal transduction pathways in breast cancer cells, including the Jak/Stat, PI3K/Akt, and MAPK pathways, leading to both pro-proliferative and anti-apoptotic downstream effects. This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

 

研究领域


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