产品概述
产品性能
免疫原
产品应用
研究背景
Tyrosinase, found in the membrane of melanosomes, is a key enzyme in the biosynthesis of melanin pigments. It is a melanocyte differentiation antigen and is expressed in normal melanocytes and malignant melanomas. Tyrosinase is implicated to be an antigen target for melanoma vaccines. This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA- quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).
研究领域
Tyrosine metabolism;Riboflavin metabolism;Melanogenesis;
