| 产品名称 |
Recombinant Human proHB-EGF (C-6His) |
| 英文名称 |
proHB-EGF/Heparin Binding EGF like Growth Factor |
| 纯度 |
Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 |
<1 EU/µg as determined by LAL test. |
| 蛋白构建 |
Recombinant Human Heparin Binding EGF like Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu20-Leu148 is expressed with a 6His tag at the C-terminus. |
| Accession |
Q99075 |
| 表达宿主 |
Human Cells |
| 种属 |
Human |
| 预测分子量 |
15.1 KDa |
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 运输方式 |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.Reconstituted protein solution can be stored at 2-8°C for 2-7 days.Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 |
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 分子别名 |
| Diphtheria toxin receptor; DTR;HEGFL; heparin-binding EGF-like growth factor; DTS; DTSF; heparin-binding epidermal growth factor; proheparin-binding EGF-like growth factor; HB-EGF; pro HB-EGF |
| 背景介绍 |
| Heparin-binding EGF-like growth factor (HB-EGF) is a 12/xad16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF/xadlike domain, and a heparin-binding motif. Mature HB/xadEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB/xadEGF shows 76% and 73% aa sequence identity with rat and mouse HB/xadEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB/xadEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non/xadmitogenic actions, while EGFR binding induces both mitogenic and non/xadmitogenic activity. |
注意事项
本司产品仅用于科研，不用于临床诊断和治疗
