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RPE65 (5T1) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

RPE65 (5T1) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

Cat: AMRe17356
★ ★ ★ ★ ★
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB,IHC-P,IP,IF-P
种属（Reactivity）：Human,Mouse,Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：RPE65
分类: 兔单克隆抗体 标签: , , , , , , , , ,

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产品概述

产品名称（Product Name）

RPE65 (5T1) Rabbit Monoclonal Antibody

描述（Description）

Recombinant rabbit monoclonal antibody

宿主（Host）

Rabbit

应用（Application）

WB,IHC,IP,IF-P

种属反应性（Reactivity）

Human,Mouse,Rat

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Unmodified

同种型（Isotype）

IgG

克隆（Clonality）

Monoclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式（Purification）

Affinity purification

 

免疫原

基因名（Gene Name）

RPE65

别名（Alternative Names）

LCA2; mRPE65; p63; rd12; Retinal pigment epithelium specific 61 kDa protein; RP20; RPE65; sRPE65;

基因ID（Gene ID）

6121

蛋白ID（SwissProt ID）

Q16518

 

产品应用

稀释比（Dilution Ratio）

WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000

蛋白分子量（Molecular Weight）

61kDa

 

研究背景

Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye- specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all- trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).

 

研究领域

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