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C14orf169/NO66 Rabbit Monoclonal Antibody【50ul/100ul买二送一】

C14orf169/NO66 Rabbit Monoclonal Antibody【50ul/100ul买二送一】

Cat: AMRe86570
★ ★ ★ ★ ★
规格：20μL 价格：￥680
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB, IP
种属（Reactivity）：Human,Mouse,Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：C14orf169/NO66
分类: 兔单克隆抗体 标签: , , , , , ,

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产品概述

产品名称（Product Name）

C14orf169/NO66 Rabbit Monoclonal Antibody

描述（Description）

Recombinant rabbit monoclonal antibody

宿主（Host）

Rabbit

应用（Application）

WB,IP

种属反应性（Reactivity）

Human,Mouse,Rat

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Unmodified

同种型（Isotype）

IgG

克隆（Clonality）

Monoclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% protective protein. Stable for 12 months from date of receipt.

纯化方式（Purification）

Affinity Purification

 

免疫原

基因名（Gene Name）

C14orf169/NO66

别名（Alternative Names）

ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169

基因ID（Gene ID）

79697

蛋白ID（SwissProt ID）

Q9H6W3

 

产品应用

稀释比（Dilution Ratio）

WB 1:500-1:2000,IP 1:50-1:100

蛋白分子量（Molecular Weight）

Calculated MW:71 kDa; Observed MW:71 kDa

 

研究背景

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

 

研究领域

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