BHLH3 (N-term) Mouse Monoclonal Antibody-EnkiLife

BHLH3 (N-term) Mouse Monoclonal Antibody

规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB
种属（Reactivity）：Human, Mouse, Rat
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：BHLH3 (N-term) SKU: AMM86123 Category: 鼠单克隆抗体 Tags: Mouse, Unconjugated, WB, Human, Mouse, Rat

说明书复制

产品概述

产品名称（Product Name）	BHLH3 (N-term) Mouse Monoclonal Antibody
描述（Description）	Mouse monoclonal Antibody
宿主（Host）	Mouse
应用（Application）	WB
种属反应性（Reactivity）	Human, Mouse, Rat

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	Mouse IgG2b
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Purified antibody in PBS with 0.05% sodium azide.
纯化方式（Purification）	Affinity Purification

免疫原

基因名（Gene Name）	BHLH3 (N-term)
别名（Alternative Names）	Class E basic helix-loop-helix protein 41, bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, hDEC2, Enhancer-of-split and hairy-related protein 1, SHARP-1, BHLHE41, BHLHB3, DEC2, SHARP1
基因ID（Gene ID）	79365
蛋白ID（SwissProt ID）	Q9C0J9

产品应用

稀释比（Dilution Ratio）	WB 1:2000-1:4000
蛋白分子量（Molecular Weight）	50.5kDa

研究背景

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

研究领域