表皮生长因子（EGFs）
多种疾病与生长因子稳态的破坏相关，表皮生长因子（EGF）家族就是如此，其表达异常与多种疾病的发生有关，如肺腺癌和其他多种癌症类型、慢性疼痛、慢性肾脏疾病和银屑病。EGF生长因子的信号传导由ErbB家族的G蛋白偶联受体介导，该家族包含四个成员（ErbB1至ErbB4）。EGF生长因子与受体的结合由EGF结构域介导，导致受体的同源或异源二聚化，并激活其细胞内C末端结构域的交叉磷酸化。受体激活可触发信号转导至参与分化、增殖、迁移或存活的多条通路，具有广泛的靶点，包括PLCϒ、STAT5、SHIP1、Abl、PTP-2c、STAT1、Syk、Vav2、RasA1、SH3BGRL、Grb2、Src、Crk、Nck、Shc和Cb1。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| proHB-EGF (C-6His) | PHH0786 | Recombinant Human proHB-EGF (C-6His) | Human | 15.1 KDa |
| EGF (C-6His) | PEM0557 | Recombinant Mouse EGF (C-6His) | Mouse | 7.2 KDa |
| BTC (N-6His) | PEM0148 | Recombinant Mouse BTC (N-6His) | Mouse | 12.2 KDa |
| NRG1Beta (71AA) | PEH1377 | Recombinant Human NRG1Beta (71AA) | Human | 8.2 KDa |
| NRG1Beta (65AA) | PEH1376 | Recombinant Human NRG1Beta (65AA) | Human | 7.5 KDa |
| NRG1Beta (245AA) | PEH1241 | Recombinant Human NRG1Beta (245AA) | Human | 26.9 KDa |
| EGF | PEH0556 | Recombinant Human EGF | Human | 6.2 KDa |
验证数据
相关产品
参考文献
1. EGFs and ERBBs--brief history and prospects. Stern DF. Semin Cell Dev Biol. 2010. [PMID: 20970513]
2. A toolkit for recombinant production of seven human EGF family growth factors in active conformation. Ferreira AS, et al. Sci Rep. 2022. [PMID: 35322149]
3. Eicosanoids and HB-EGF/EGFR in cancer. Yang CC, et al. Cancer Metastasis Rev. 2018. [PMID: 29936588]
4. Epidermal growth factor on the healing of human subacute tympanic membrane perforation. Liu Y. Am J Otolaryngol. 2020. [PMID: 31948693]
5. The ErbB/HER family of protein-tyrosine kinases and cancer. Roskoski R Jr. Pharmacol Res. 2014. [PMID: 24269963]
6. Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis. Holowka D, et al. Biochim Biophys Acta Biomembr. 2017. [PMID: 28024796]
