产品概述
产品性能
免疫原
产品应用
研究背景
Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
研究领域