MICA/B Rabbit Monoclonal Antibody-EnkiLife

MICA/B Rabbit Monoclonal Antibody

规格：20μL 价格：￥680
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB, IHC-P
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：MICA/B SKU: AMRe87389 Category: 兔单克隆抗体 Tags: Rabbit, Unconjugated, WB, IHC-P, Human

说明书复制

产品概述

产品名称（Product Name）	MICA/B Rabbit Monoclonal Antibody
描述（Description）	Rabbit Monoclonal antibody
宿主（Host）	Rabbit
应用（Application）	WB, IHC-P
种属反应性（Reactivity）	Human

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
纯化方式（Purification）	Affinity Purification

免疫原

基因名（Gene Name）	MICA/B
别名（Alternative Names）	MIC-A; PERB11.1
基因ID（Gene ID）	100507436
蛋白ID（SwissProt ID）	Q29980

产品应用

稀释比（Dilution Ratio）	WB: 1:1000-1:5000 IHC-P: 1:200-1:500
蛋白分子量（Molecular Weight）	Calculated MW:43 kDa; Observed MW:60,75 kDa

研究背景

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]