Bcl10 (4U16) Rabbit Monoclonal Antibody-EnkiLife

Bcl10 (4U16) Rabbit Monoclonal Antibody

规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB,IHC-P
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：BCL10 SKU: AMRe07496 Category: 兔单克隆抗体 Tags: Human, WB, IHC-P, Unconjugated, Rabbit, -

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产品概述

产品名称（Product Name）	Bcl10 (4U16) Rabbit Monoclonal Antibody
描述（Description）	Rabbit Monoclonal Antibody
宿主（Host）	Rabbit
应用（Application）	WB,IHC-P
种属反应性（Reactivity）	Human

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
纯化方式（Purification）	Affinity purification

免疫原

基因名（Gene Name）	BCL10
别名（Alternative Names）	B cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; Bcl10; CARD containing molecule enhancing NF kappa B; CARD like apoptotic protein; Caspase recruiting domain containing protein; cE10; Cellular E10; CIPER; hCLAP; Mammalian CARD-containing adapter molecule E10; R-RCD1;
基因ID（Gene ID）	8915
蛋白ID（SwissProt ID）	O95999

产品应用

稀释比（Dilution Ratio）	WB 1:1000-1:5000, IHC-P/IF-P 1:200-1:500
蛋白分子量（Molecular Weight）	26kDa

研究背景

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:25365219, PubMed:24074955). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:27777308, PubMed:24074955). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:27777308, PubMed:24074955). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815).