phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)(14A10) Rabbit Monoclonal Antibody

phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)(14A10) Rabbit Monoclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):PLCG1
SKU: AMRe05243 Category: 兔单克隆抗体 Tags: , , , ,

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产品概述

产品名称(Product Name)

phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)(14A10) Rabbit Monoclonal Antibody

描述(Description)

Recombinant rabbit monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Phosphorylated

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% protective protein.

纯化方式(Purification)

Affinity purification

 

免疫原

基因名(Gene Name)

PLCG1

别名(Alternative Names)

PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1;

基因ID(Gene ID)

5335

蛋白ID(SwissProt ID)

P19174

 

产品应用

稀释比(Dilution Ratio)

WB 1:1000-1:2000

蛋白分子量(Molecular Weight)

149kDa

 

研究背景

Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814).

 

研究领域

Cardiovascular


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