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MBD1 (3J6) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

MBD1 (3J6) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

Cat: AMRe13680
★ ★ ★ ★ ★
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB,IHC-P,ICC/IF
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：MBD1
分类: 兔单克隆抗体 标签: , , , , , ,

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产品概述

产品名称（Product Name）

MBD1 (3J6) Rabbit Monoclonal Antibody

描述（Description）

Recombinant rabbit monoclonal antibody

宿主（Host）

Rabbit

应用（Application）

WB,IHC,ICC/IF

种属反应性（Reactivity）

Human

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Unmodified

同种型（Isotype）

IgG

克隆（Clonality）

Monoclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式（Purification）

Affinity purification

 

免疫原

基因名（Gene Name）

MBD1

别名（Alternative Names）

CXXC 3; Mbd1; MECP1 COMPLEX; PCM1; RFT;

基因ID（Gene ID）

4152

蛋白ID（SwissProt ID）

Q9UIS9

 

产品应用

稀释比（Dilution Ratio）

WB 1:500-1:2000,IHC 1:100-1:200,ICC/IF 1:100-1:200

蛋白分子量（Molecular Weight）

67kDa

 

研究背景

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

 

研究领域

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