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Kininogen 1 (13J10) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

Kininogen 1 (13J10) Rabbit Monoclonal Antibody【50ul/100ul买二送一】

Cat: AMRe13024
★ ★ ★ ★ ★
规格：50μL 价格：￥1350
规格：100μL 价格：￥2250
应用（Application）：WB,IHC-P,IP,IF-P
种属（Reactivity）：Human
偶联物（Conjugate）：Unconjugated
基因名（Gene Name）：KNG1
分类: 兔单克隆抗体 标签: , , , , , , ,

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产品概述

产品名称（Product Name）

Kininogen 1 (13J10) Rabbit Monoclonal Antibody

描述（Description）

Recombinant rabbit monoclonal antibody

宿主（Host）

Rabbit

应用（Application）

WB,IHC,IP,IF-P

种属反应性（Reactivity）

Human

 

产品性能

偶联物（Conjugation）

Unconjugated

修饰（Modification）

Unmodified

同种型（Isotype）

IgG

克隆（Clonality）

Monoclonal

形式（Form）

Liquid

存放说明（Storage）

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液（Buffer）

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式（Purification）

Affinity purification

 

免疫原

基因名（Gene Name）

KNG1

别名（Alternative Names）

BDK; Bradykinin; HMWK; Kallidin I; Kallidin II; KNG; KNG1; WILLIAMS FACTOR;

基因ID（Gene ID）

3827

蛋白ID（SwissProt ID）

P01042

 

产品应用

稀释比（Dilution Ratio）

WB 1:2000-1:20000,IHC 1:100-1:200,IP 1:10-1:100,IF-P 1:100-1:200

蛋白分子量（Molecular Weight）

72kDa

 

研究背景

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

 

研究领域

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