DAB2 Rabbit Monoclonal Antibody

DAB2 Rabbit Monoclonal Antibody

Cat: AMRe03298
★ ★ ★ ★ ★
规格:20μL 价格:¥600
规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB,ICC/IF,IP

种属(Reactivity):Human,Rat
偶联物(Conjugate):Unconjugated
基因名(Gene Name):DAB2

分类: 兔单克隆抗体 标签: , , , , , , ,

说明书 复制

产品概述

产品名称(Product Name)

DAB2 Rabbit Monoclonal Antibody

描述(Description)

Recombinant rabbit monoclonal antibody

宿主(Host)

Rabbit

应用(Application)

WB,ICC/IF,IP

种属反应性(Reactivity)

Human,Rat

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

DAB2

别名(Alternative Names)

DOC2; DOC-2

基因ID(Gene ID)

1601

蛋白ID(SwissProt ID)

P98082

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50

蛋白分子量(Molecular Weight)

Calculated MW: 82 kDa; Observed MW: 96 kDa

 

研究背景

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

 

研究领域

Signal Transduction


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