产品概述
产品性能
免疫原
ΦX174 bacteriophage-derived synthetic DNA/RNA
产品应用
研究背景
The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional
activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to
predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-
loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA-RNA hybrids but also binds
RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and
structural dependency since R-loop sequence affects binding affinity.
注意事项
For research use only
