RIPK3 Mouse Monoclonal Antibody

RIPK3 Mouse Monoclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):RIPK3
SKU: AMM86115 Category: 鼠单克隆抗体 Tags: , , , ,

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产品概述

产品名称(Product Name)

RIPK3 Mouse Monoclonal Antibody

描述(Description)

Mouse monoclonal Antibody

宿主(Host)

Mouse

应用(Application)

WB

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

Mouse IgG1

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Purified antibody in PBS with 0.05% sodium azide.

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

RIPK3

别名(Alternative Names)

Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIPK3, RIP3

基因ID(Gene ID)

11035

蛋白ID(SwissProt ID)

Q9Y572

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:2000

蛋白分子量(Molecular Weight)

56.9kDa

 

研究背景

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

 

研究领域

Apoptosis


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