APAF1 Mouse Monoclonal Antibody

APAF1 Mouse Monoclonal Antibody

规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):ICC,FC,ELISA

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):APAF1
SKU: AMM82002 Category: 鼠单克隆抗体 Tags: , , , , ,

说明书 复制

产品概述

产品名称(Product Name)

APAF1 Mouse Monoclonal Antibody

描述(Description)

Mouse monoclonal Antibody

宿主(Host)

Mouse

应用(Application)

ICC,ELISA,FC

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

Mouse IgG2b

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Purified antibody in PBS with 0.05% sodium azide

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

APAF1

别名(Alternative Names)

CED4; APAF-1

基因ID(Gene ID)

317

蛋白ID(SwissProt ID)

O14727 

 

产品应用

稀释比(Dilution Ratio)

ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400

蛋白分子量(Molecular Weight)

141.8kDa

 

研究背景

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

 

研究领域


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