MCL-1 Mouse Monoclonal Antibody

MCL-1 Mouse Monoclonal Antibody

Cat: AMM80516
★ ★ ★ ★ ★
规格:50μL 价格:¥1350
规格:100μL 价格:¥2250
应用(Application):WB,IHC,ICC,ELISA

种属(Reactivity):Human
偶联物(Conjugate):Unconjugated
基因名(Gene Name):MCL-1

分类: 鼠单克隆抗体 标签: , , , , , , ,

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产品概述

产品名称(Product Name)

MCL-1 Mouse Monoclonal Antibody

描述(Description)

Mouse monoclonal Antibody

宿主(Host)

Mouse

应用(Application)

WB,IHC,ICC,ELISA

种属反应性(Reactivity)

Human

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

Mouse IgG1

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Purified antibody in PBS with 0.05% sodium azide

纯化方式(Purification)

Affinity Purification

 

免疫原

基因名(Gene Name)

MCL-1

别名(Alternative Names)

EAT, MCL1L, MCL1S

基因ID(Gene ID)

4170

蛋白ID(SwissProt ID)

Q07820

 

产品应用

稀释比(Dilution Ratio)

WB 1:500-1:2000,IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000

蛋白分子量(Molecular Weight)

37kDa

 

研究背景

Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that
increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or
exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related
protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This
monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

 

研究领域

Apoptosis


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