白细胞介素（ILs）及其受体
白细胞介素（ILs）是一组细胞因子（分泌蛋白和信号分子），最初被发现由白细胞（leukocytes）表达。免疫系统的功能在很大程度上依赖于白细胞介素，已经描述了多种白细胞介素的罕见缺陷，这些缺陷都表现为自身免疫疾病或免疫缺陷。大多数白细胞介素由辅助性CD4 T淋巴细胞合成，也可通过单核细胞、巨噬细胞和内皮细胞合成。它们促进T和B淋巴细胞以及造血细胞的发育和分化。许多白细胞介素根据结构相似性、受体链使用和功能特性被分类为不同的家族。例如IL-1家族、IL-2家族、IL-6家族、IL-10家族、IL-12家族、IL-17家族等。每个家族都有独特的特征，在免疫调节和炎症中发挥特定的作用。
白细胞介素受体（ILRs）是一类广泛表达于免疫细胞和非免疫细胞表面的跨膜蛋白家族。其核心功能是特异性结合白细胞介素（ILs）并启动细胞内信号转导，从而调节机体免疫应答、细胞增殖与分化以及生理和病理过程。目前已鉴定的38种白细胞介素（IL-1至IL-38）均需与相应的ILRs结合才能发挥作用，两者之间的特异性结合是白细胞介素功能实现的首要步骤。
根据结构特征和信号传导机制，ILRs家族主要分为四类：第一类是IL-17受体家族，包含五个成员（IL-17RA至IL-17RE）。它们多以复合物形式（如IL-17RA/RC复合物）介导促炎和免疫应答信号，保守的胞内"SEFIR"结构域是信号转导的关键基础；第二类是Ig样受体，属于免疫球蛋白超家族（IgSF），包含1-7个Ig样结构域。典型成员包括IL-1受体和IL-18受体，广泛参与炎症启动和免疫调节；第三类是I型受体（又称红细胞生成素受体家族），大多由多个亚基组成。其胞外区含有保守的半胱氨酸残基和WSXWS序列（Trp-Ser-X-Trp-Ser），涵盖IL-2、IL-3、IL-6等受体，调控免疫细胞增殖和造血；第四类是II型受体（又称干扰素受体家族），其胞外区含有四个保守的半胱氨酸残基但无WSXWS序列。它们多以异二聚体形式存在，如IL-10和IL-22受体，常与Janus激酶（JAK）结合传递抗炎或抗病毒信号。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| IL-11 | PPH0861 | Recombinant Human IL-11 | Human | 19 kDa |
| IL-2 (C-6His) | PHR0994 | Recombinant Rat IL-2 (C-6His) | Rat | 16.3 kDa |
| IL-12 (C-6His) | PHR0985 | Recombinant Rat IL-12 (C-6His) | Rat | 36.7&22.6 kDa |
| IL-5 (C-6His) | PHM2084 | Recombinant Mouse IL-5 (C-6His) | Mouse | 13.9 kDa |
| IL-11 (C-Fc) | PHM1933 | Recombinant Mouse IL-11 (C-Fc) | Mouse | 46.3 kDa |
| IL-7 (C-6His) | PHM1013 | Recombinant Mouse IL-7 (C-6His) | Mouse | 15.9 kDa |
| IL-3 (C-6His) | PHM1004 | Recombinant Mouse IL-3 (C-6His) | Mouse | 16.5 kDa |
| IL-27 (C-6His) | PHM1002 | Recombinant Mouse IL-27 (C-6His) | Mouse | 49 kDa |
| IL-12 | PHM0984 | Recombinant Mouse IL-12 | Mouse | 35.8&21.7 kDa |
| IL-13 (106AA,C-6His) | PHM0868 | Recombinant Mouse IL-13 (106AA,C-6His) | Mouse | 12.7 kDa |
| IL-13 (110AA, C-6His) | PHM0867 | Recombinant Mouse IL-13 (110AA, C-6His) | Mouse | 13.1 kDa |
| IL-1a (C-Fc) | PHH2348 | Recombinant Human IL-1a (C-Fc) | Human | 44.9 kDa |
| IL-13 (C-mFc) | PHH2222 | Recombinant Human IL-13 (C-mFc) | Human | 38.7 kDa |
| IL-13 (C-Fc) | PHH2151 | Recombinant Human IL-13 (C-Fc) | Human | 39.2 KDa |
| IL-4 (C-Fc) | PHH2150 | Recombinant Human IL-4 (C-Fc) | Human | 41.9 KDa |
| IL-5 (C-mFc) | PHH2112 | Recombinant Human IL-5 (C-mFc) | Human | 39.8 KDa |
| IL-2 Superkine (Mutant,C-6His) | PHH1918 | Recombinant Human IL-2 Superkine (Mutant,C-6His) | Human | 16.5 KDa |
| IL-7 (C-6His) | PHH0937 | Recombinant Human IL-7 (C-6His) | Human | 18.4 KDa |
| IL-5 (C-6His) | PHH0932 | Recombinant Human IL-5 (C-6His) | Human | 14.2 KDa |
| IL-4 (C-6His) | PHH0931 | Recombinant Human IL-4 (C-6His) | Human | 16 KDa |
| IL-4 (Mammalian) | PHH0929 | Recombinant Human IL-4 (Mammalian) | Human | 14.97 KDa |
| IL-3 (C-6His) | PHH0920 | Recombinant Human IL-3 (C-6His) | Human | 16.1 KDa |
| IL-2 (C-6His) | PHH0897 | Recombinant Human IL-2 (C-6His) | Human | 16.4 KDa |
| IL-18 (C-6His) | PHH0881 | Recombinant Human IL-18 (C-6His) | Human | 19.25 KDa |
| IL-13 (C-6His) | PHH0866 | Recombinant Human IL-13 (C-6His) | Human | 13.4 KDa |
| IL-12 | PHH0862 | Recombinant Human IL-12 | Human | 22.5&34.7 KDa |
| IL-10 | PHH0857 | Recombinant Human IL-10 | Human | 18.6 KDa |
| IL-8 (C-6His) | PHH0480 | Recombinant Human IL-8 (C-6His) | Human | 10.1 KDa |
| IL-1b (C-6His) | PEV0972 | Recombinant Cavia porcellus IL-1b (C-6His) | Cavia porcellus | 18.2 KDa |
| IL-1a | PER0971 | Recombinant Rat IL-1a | Rat | 17.9 KDa |
| IL-21 (N-6His) | PEM0996 | Recombinant Mouse IL-21 (N-6His) | Mouse | 16.5 KDa |
| IL-4 | PEM0930 | Recombinant Mouse IL-4 | Mouse | 13.4 KDa |
| IL-21 | PEM0904 | Recombinant Mouse IL-21 | Mouse | 14.4 KDa |
| IL-2 | PEM0898 | Recombinant Mouse IL-2 | Mouse | 17.4 KDa |
| IL-1b | PEM0890 | Recombinant Mouse IL-1b | Mouse | 17.4 KDa |
| IL-1a | PEM0887 | Recombinant Mouse IL-1a | Mouse | 18 KDa |
| IL-18 (N-6His) | PEM0883 | Recombinant Mouse IL-18 (N-6His) | Mouse | 19.7 KDa |
| IL-16 (N-6His) | PEM0875 | Recombinant Mouse IL-16 (N-6His) | Mouse | 14.5 KDa |
| IL-13 (106AA) | PEM0869 | Recombinant Mouse IL-13 (106AA) | Mouse | 11.7 KDa |
| IL-10 | PEM0858 | Recombinant Mouse IL-10 | Mouse | 18.9 KDa |
| OSM (N-6His) | PEH2009 | Recombinant Human OSM (N-6His) | Human | 24.44 KDa |
| IL-2 (aldesleukin) | PEH1851 | Recombinant Human IL-2 (aldesleukin) | Human | 15.5 KDa |
| IL-37 | PEH1006 | Recombinant Human IL-37 | Human | 18.7 KDa |
| IL-7 | PEH0936 | Recombinant Human IL-7 | Human | 17.5 KDa |
| IL-4 (E. coli) | PEH0928 | Recombinant Human IL-4 (E. coli) | Human | 15.1 KDa |
| IL-31 | PEH0921 | Recombinant Human IL-31 | Human | 15.8 KDa |
| IL-3 (N-6His) | PEH0919 | Recombinant Human IL-3 (N-6His) | Human | 16.6 KDa |
| IL-21 | PEH0903 | Recombinant Human IL-21 | Human | 15.6 KDa |
| IL-20 | PEH0899 | Recombinant Human IL-20 | Human | 17.7 KDa |
| IL-2 | PEH0896 | Recombinant Human IL-2 | Human | 15.5 KDa |
| IL-1F10 | PEH0889 | Recombinant Human IL-1F10 | Human | 16.9 KDa |
| IL-1a | PEH0888 | Recombinant Human IL-1a | Human | 18 KDa |
| IL-1b | PEH0886 | Recombinant Human IL-1b | Human | 17.5 KDa |
| IL-18 | PEH0882 | Recombinant Human IL-18 | Human | 18.2 KDa |
| IL-16 | PEH0874 | Recombinant Human IL-16 | Human | 13.4 KDa |
| IL-15 | PEH0870 | Recombinant Human IL-15 | Human | 12.5 KDa |
| CNTF | PEH0426 | Recombinant Human CNTF | Human | 22.93 KDa |
| IL-2RG (C-Fc) | PHM0993 | Recombinant Mouse IL-2RG (C-Fc) | Mouse | 55.1 KDa |
| IL-1R2 (C-Fc) | PHM0977 | Recombinant Mouse IL-1R2 (C-Fc) | Mouse | 64.9 KDa |
| IL-1R2 (C-6His) | PHM0976 | Recombinant Mouse IL-1R2 (C-6His) | Mouse | 39 KDa |
| IL-15RA (C-Fc) | PHM0873 | Recombinant Mouse IL-15RA (C-Fc) | Mouse | 45.5 KDa |
| IL18R1 (C-6His) | PHH2417 | Recombinant Human IL18R1 (C-6His) | Human | 36.6 KDa |
| IL-15RA&IL-15 Complex (C-Fc) | PHH2394 | Recombinant Human IL-15RA&IL-15 Complex (C-Fc) | Human | 34.4&12.8 KDa |
| IL-1R2 (C-Fc) | PHH0979 | Recombinant Human IL-1R2 (C-Fc) | Human | 64.5 KDa |
| IL-1R2 (C-6His) | PHH0978 | Recombinant Human IL-1R2 (C-6His) | Human | 38.6 KDa |
| IL-2RG (C-Fc) | PHH0918 | Recombinant Human IL-2RG (C-Fc) | Human | 55.4 KDa |
| IL-22RA2 (C-Fc) | PHH0909 | Recombinant Human IL-22RA2 (C-Fc) | Human | 51.8 KDa |
| IL-22RA2 (C-6His) | PHH0908 | Recombinant Human IL-22RA2 (C-6His) | Human | 25.7 KDa |
| IL-20RB (C-Fc) | PHH0902 | Recombinant Human IL-20RB (C-Fc) | Human | 49.6 KDa |
| IL-20RA (C-Fc) | PHH0901 | Recombinant Human IL-20RA (C-Fc) | Human | 52.4 KDa |
| IL-20RA (C-6His) | PHH0900 | Recombinant Human IL-20RA (C-6His) | Human | 26.3 KDa |
| IL-1RAcP (Q9NPH3-2, C-Fc-6His) | PHH0893 | Recombinant Human IL-1RAcP (Q9NPH3-2, C-Fc-6His) | Human | 66.7 KDa |
| IL-1RAcP (Q9NPH3-2, C-6His) | PHH0892 | Recombinant Human IL-1RAcP (Q9NPH3-2, C-6His) | Human | 39.75 KDa |
| IL-15RA&IL-15 (C-Fc) | PHH0872 | Recombinant Human IL-15RA&IL-15 (C-Fc) | Human | 46.9 KDa |
| IL-15RA (C-Fc) | PHH0871 | Recombinant Human IL-15RA (C-Fc) | Human | 42.2 KDa |
| IL-10RB (C-Fc) | PHH0860 | Recombinant Human IL-10RB (C-Fc) | Human | 50.6 KDa |
| IL-10RB (C-6His) | PHH0859 | Recombinant Human IL-10RB (C-6His) | Human | 24.5 KDa |
| IL-1RA | PEM0894 | Recombinant Mouse IL-1RA | Mouse | 17.5 KDa |
| IL-1RA | PEH0891 | Recombinant Human IL-1RA | Human | 17.26 KDa |
验证数据
相关产品
参考文献
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