干扰素（IFNs）
干扰素（IFN）家族包含三类：I型（IFN-α/β/κ/ε/ω）、II型（IFN-γ）和III型（IFN-λ1/2/3）。I型IFN在病毒或核酸感知后迅速产生，通过IFNAR1/2信号激活JAK-STAT1/2通路，诱导数百个干扰素刺激基因（ISG）的表达，建立抗病毒状态。II型IFN由NK细胞和Th1细胞分泌，通过IFNGR1/2增强巨噬细胞激活和抗原提呈。III型IFN通过IFNLR1/IL-10R2在黏膜表面局部发挥作用，同样使用STAT1/2通路。除抗病毒防御外，IFN还调节细胞增殖、凋亡和肿瘤免疫监视；其失调是慢性感染、自身免疫和癌症免疫逃逸的基础，使其成为基于IFN的疗法和免疫检查点策略的核心靶点。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| Limitin (C-6His) | PHM0970 | Recombinant Mouse Limitin (C-6His) | Mouse | 19.5 kDa |
| IFN gamma (C-6His) | PHM0969 | Recombinant Mouse IFN gamma (C-6His) | Mouse | 16.6 KDa |
| IFN gamma | PHM0968 | Recombinant Mouse IFN gamma | Mouse | 15.5 KDa |
| IL-29 (C-10His) | PHH1854 | Recombinant Human IL-29 (C-10His) | Human | 21.4 KDa |
| IL-28B | PHH1003 | Recombinant Human IL-28B | Human | 19.6 KDa |
IL-28A (C-6His) | PHH0965 | Recombinant Human IL-28A (C-6His) | Human | 20.6 kDa |
IFNW1 (C-6His) | PHH0835 | Recombinant Human IFNW1 (C-6His) | Human | 21.1 kDa |
| IL-28B (C-6His) | PHH0834 | Recombinant Human IL-28B (C-6His) | Human | 20.67 kDa |
| IFN gamma | PHH0833 | Recombinant Human IFN gamma | Human | 16.8 kDa |
| IFN alpha6 (C-6His) | PHH0827 | Recombinant Human IFN alpha6 (C-6His) | Human | 21.1 kDa |
| IFN alpha4 (C-6His) | PHH0826 | Recombinant Human IFN alpha4 (C-6His) | Human | 21.1 kDa |
| IFN alpha1 (C-6His) | PHH0823 | Recombinant Human IFN alpha1 (C-6His) | Human | 20.4 kDa |
| IFN alpha2 | PEM0967 | Recombinant Mouse IFN alpha2 | Mouse | 19.5 kDa |
| IFN gamma (E. coli) | PEM0832 | Recombinant Mouse IFN gamma (E. coli) | Mouse | 15.7 kDa |
| IFN gamma (E. coli) | PEH0831 | Recombinant Human IFN gamma (E. coli) | Human | 16.88 kDa |
| IFN alpha2b | PEH0825 | Recombinant Human IFN alpha2b | Human | 19.4 kDa |
| IFN alpha2a | PEH0824 | Recombinant Human IFN alpha2a | Human | 19.24 kDa |
验证数据
Recombinant Mouse Limitin (C-6His) (产品货号: PHM0970） Recombinant Human IL-29 (C-10His) (产品货号: PHH1854)
相关产品
参考文献
1. Type I IFN family members: similarity, differences and interaction. Capobianchi MR, et al. Cytokine Growth Factor Rev. 2015. [PMID: 25466633]
2. Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion. Broggi A, et al. J Exp Med. 2020. [PMID: 31821443]
3. The Role of Structure in the Biology of Interferon Signaling. Walter MR. Front Immunol. 2020. [PMID: 33281831]
