成纤维细胞生长因子（FGFs）
成纤维细胞生长因子（FGF）家族由一组结构相关的信号蛋白组成，在胚胎发育、细胞增殖、分化、迁移、血管生成、组织修复和代谢调节中发挥关键作用。在人类中，FGF家族包括18个经典成员（FGF1–FGF10和FGF16–FGF23），根据序列同源性和功能特征分为六个亚家族。大多数FGF以旁分泌方式在局部发挥作用，而FGF19亚家族（FGF19、FGF21和FGF23）则以内分泌方式发挥作用，调节胆汁酸、葡萄糖和磷酸盐的全身代谢。FGF通过与FGF受体（FGFRs）结合，激活丝裂原活化蛋白激酶（MAPK）和磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/AKT）等下游信号通路，从而影响各种细胞过程。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| FGF-21 (C-6His) | PHV0660 | Recombinant Cynomolgus FGF-21 (C-6His) | Cynomolgus | 20.2 KDa |
| FGF-21 (C-6His) | PHM2199 | Recombinant Mouse FGF-21 (C-6His) | Mouse | 20.8 KDa |
| FGF-17 (C-6His) | PHH1900 | Recombinant Human FGF-17 (C-6His) | Human | 22.64 KDa |
| KGF (C-6His) | PHH0662 | Recombinant Human KGF (C-6His) | Human | 20 KDa |
| FGF-8b | PEV0663 | Recombinant Human/Mouse FGF-8b | Human/Mouse | 22.5 KDa |
| FGFb | PER0657 | Recombinant Rat FGFb | Rat | 16.2 KDa |
| FGF-4 | PEM2172 | Recombinant Mouse FGF-4 | Mouse | 15.2 KDa |
| FGF-9 (C-6His) | PEM0664 | Recombinant Mouse FGF-9 (C-6His) | Mouse | 24.4 KDa |
| FGFb | PEM0647 | Recombinant Mouse FGFb | Mouse | 17.15 KDa |
| FGF-4 (136AA) | PEH2174 | Recombinant Human FGF-4 (136AA) | Human | 15.1 KDa |
| FGF-4 (153AA) | PEH0661 | Recombinant Human FGF-4 (153AA) | Human | 16.9 KDa |
| FGFb (Q65I,C96S,N111G) | PEH0659 | Recombinant Human FGFb (Q65I,C96S,N111G) | Human | 17.2 KDa |
| FGFb(K128N) | PEH0658 | Recombinant Human FGFb(K128N) | Human | 17.2 KDa |
| FGF-10 | PEH0656 | Recombinant Human FGF-10 | Human | 19.5 KDa |
| FGF-9 | PEH0653 | Recombinant Human FGF-9 | Human | 23.44 KDa |
| KGF | PEH0652 | Recombinant Human KGF | Human | 18.9 KDa |
| FGF-21 (N-6His) | PEH0651 | Recombinant Human FGF-21 (N-6His) | Human | 21.69 KDa |
| FGFb (146AA) | PEH0650 | Recombinant Human FGFb (146AA) | Human | 16.3 KDa |
| FGFb (155AA) | PEH0649 | Recombinant Human FGFb (155AA) | Human | 17.3 KDa |
| FGFb (157AA) | PEH0648 | Recombinant Human FGFb (157AA) | Human | 17.4 KDa |
| FGF-19 (N-6His) | PEH0646 | Recombinant Human FGF-19 (N-6His) | Human | 23.5 KDa |
| FGF-17 | PEH0645 | Recombinant Human FGF-17 | Human | 22.6 KDa |
| FGF-12 | PEH0644 | Recombinant Human FGF-12 | Human | 20.45 KDa |
| FGFa (140AA) | PEH0643 | Recombinant Human FGFa (140AA) | Human | 16 KDa |
| FGFa (154AA) | PEH0642 | Recombinant Human FGFa (154AA) | Human | 17.3 KDa |
验证数据
相关产品
参考文献
1. Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance. Edirisinghe O, et al. Biomolecules. 2024. [PMID: 39766329]
2. FGF/FGFR signaling in health and disease. Xie Y, et al. Signal Transduct Target Ther. 2020. [PMID: 32879300]
3. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Wiedemann M, et al. Genomics. 2000. [PMID: 11031111]
4. Exploring mechanisms of FGF signalling through the lens of structural biology. Goetz R, et al. Nat Rev Mol Cell Biol. 2013. [PMID: 23403721]
5. Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting. Farrell B, et al. Biochem Soc Trans. 2018. [PMID: 30545934]
6. Canonical fibroblast growth factors in viral infection. Lottini G, et al. Rev Med Virol. 2023. [PMID: 37119022]
