自噬（Autophagy）
自噬是一种自我降解过程，在机体发育关键阶段以及营养应激条件下，起到平衡能量供给的重要作用。自噬还承担着细胞“管家”功能：清除错误折叠或聚集的蛋白质、清理受损细胞器（线粒体、内质网、过氧化物酶体），同时清除胞内病原体。因此自噬普遍被视作细胞存活机制，但自噬调控异常同样会引发非凋亡性细胞死亡。
自噬对细胞器、核糖体与蛋白聚集体的清除分为非选择性与选择性两种类型，目前选择性自噬的调控机制尚未完全阐明。除清除胞内聚集体与受损细胞器外，自噬还参与调控细胞衰老、细胞膜抗原呈递，维持基因组稳定、抑制细胞坏死，在肿瘤、神经退行性疾病、心肌病、糖尿病、肝病、自身免疫病与感染性疾病的防控中发挥关键作用。
产品列表
| 靶标 | 货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|
| ATG12 | AMRe83957 | ATG12 Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,ICC,FC,IP |
| ATG16L1 | AMRe21136 | ATG16L1 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| ATG3 | AMRe01690 | ATG3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF |
| AMRe21180 | ATG3 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA | |
| ATG5 | AMRe21348 | ATG5 Rabbit Monoclonal antibody | Human,Mouse,Rat,Chicken | WB,IHC,IF,ELISA,IP |
| ATG7 | AMRe21471 | ATG7 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| Bcl2 | AMM03611 | Bcl2 (9A4) Mouse Monoclonal Antibody | Human,Rat,Mouse | WB |
| Beclin 1 | AMRe04047 | Beclin 1 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| AMRe21322 | Beclin 1 Rabbit Monoclonal antibody | Human,Mouse,Rat,Chicken | WB,IHC,IF,ELISA,IP | |
| LAMP1 | AMRe87845 | LAMP1 Rabbit Monoclonal Antibody | Mouse | WB,IHC,ICC/IF,FC,IP |
| LAMP2 | AMRe01588 | LAMP2 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| AMRe21531 | LAMP2 Rabbit Monoclonal antibody | Human,Mouse | WB,IHC,ICC/IF,ELISA,IP | |
| mTOR | AMRe14217 | mTOR (1L6) Rabbit Monoclonal Antibody | Human,Mouse,Rat,Chicken,Bovine,Pig | WB,IHC,IF,IP,ELISA |
| RAB7 | AMRe21482 | Rab7 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| SQSTM1/p62 | AMRe03796 | SQSTM1/p62 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| ULK1 | AMRe19620 | ULK1 (3G10) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IF,IP,ELISA |
| AMRe83955 | ULK1 Rabbit Monoclonal | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC | |
| VAMP8 | AMRe19708 | VAMP8 (8R11) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP |
相关产品
参考文献
- Autophagy: Regulator of cell death. Liu, S., et al. Cell Death Dis. 2023. [PMID: 37794028]
- Autophagy: cellular and molecular mechanisms. Glick D, et al. J Pathol. 2010. [PMID: 20225336]
- An overview of autophagy: morphology, mechanism, and regulation. Parzych KR, et al. Antioxid Redox Signal. 2014. [PMID: 23725295]
- The role of autophagy in viral infections. Chen T, et al. J Biomed Sci. 2023. [PMID: 36653801]
- Emerging role of the Hippo pathway in autophagy. Wang D, et al. Cell Death Dis. 2020. [PMID: 33082313]
