趋化因子(Chemokines)
趋化因子是一类小型可溶性蛋白质家族的成员，最初因它们的黏附控制、趋化作用和白细胞激活能力而被发现。然而，现在已知它们还参与其他同样重要的功能，即血管生成、造血、胚胎发育、B细胞和T细胞发育、树突状细胞成熟、炎症、感染、肿瘤生长和转移。因此，对趋化因子及其受体的兴趣日益增加，不仅因为趋化因子的化学吸引特性，还因为它们对不直接涉及白细胞迁移的免疫过程的贡献。根据N端前两个保守半胱氨酸残基的数量和间距，趋化因子被分为四个亚家族（CXC、CC、CX3C和C），并通过与G蛋白偶联受体结合来介导其功能。这种相互作用可能导致多种信号转导通路，具体取决于激活的亚基和效应蛋白。它触发一系列细胞内事件，从基因转录到细胞骨架重排和趋化作用。细胞群体尤其是白细胞的迁移模式与趋化因子受体的表达密切相关。
产品列表
| 靶点 | 产品货号 | 产品名称 | 反应性 | 预测分子量 |
|---|---|---|---|---|
| CCL2 (C-6His) | PHR2396 | Recombinant Rat CCL2 (C-6His) | Rat | 14.9 kDa |
| CXCL9 (C-6His) | PHM1888 | Recombinant Mouse CXCL9 (C-6His) | Mouse | 13 KDa |
| CXCL16 (C-6His) | PHM0473 | Recombinant Mouse CXCL16 (C-6His) | Mouse | 20.1 KDa |
| CXCL1 (C-6His) | PHM0463 | Recombinant Mouse CXCL1 (C-6His) | Mouse | 9.4 KDa |
| CCL8 (C-6His) | PHM0257 | Recombinant Mouse CCL8 (C-6His) | Mouse | 9.8 KDa |
| CCL2 (C-6His) | PHM0251 | Recombinant Mouse CCL2 (C-6His) | Mouse | 14.7 KDa |
| CXCL6 (C-6His) | PHH2136 | Recombinant Human CXCL6 (C-6His) | Human | 9.35 KDa |
| CXCL9 (C-6His) | PHH0483 | Recombinant Human CXCL9 (C-6His) | Human | 12.76 KDa |
| IL-8 (C-6His) | PHH0480 | Recombinant Human IL-8 (C-6His) | Human | 10.1 KDa |
| CXCL7 (C-6His) | PHH0479 | Recombinant Human CXCL7 (C-6His) | Human | 11.3 KDa |
| CXCL4 (C-6His) | PHH0476 | Recombinant Human CXCL4 (C-6His) | Human | 8.8 KDa |
| CXCL10 (C-Fc-6His) | PHH0466 | Recombinant Human CXCL10 (C-Fc-6His) | Human | 36.6 KDa |
| CXCL1 (C-6His) | PHH0465 | Recombinant Human CXCL1 (C-6His) | Human | 8.9 KDa |
| CCL8 (C-6His) | PHH0274 | Recombinant Human CCL8 (C-6His) | Human | 9.95 KDa |
| CCL3L1 (C-6His) | PHH0271 | Recombinant Human CCL3L1 (C-6His) | Human | 8.82 KDa |
| CCL24 (C-6His) | PHH0265 | Recombinant Human CCL24 (C-6His) | Human | 11.5 KDa |
| CCL14 (C-6His) | PHH0260 | Recombinant Human CCL14 (C-6His) | Human | 9.71 KDa |
| CCL17 (C-6His) | PHH0250 | Recombinant Human CCL17 (C-6His) | Human | 9.1 KDa |
| CCL5 (N-6His) | PER0256 | Recombinant Rat CCL5 (N-6His) | Rat | 10 KDa |
| CXCL12 | PEM1576 | Recombinant Mouse CXCL12 | Mouse | 8.1 KDa |
| CXCL2 | PEM0464 | Recombinant Mouse CXCL2 | Mouse | 7.9 KDa |
| CCL9 | PEM0275 | Recombinant Mouse CCL9 | Mouse | 11.6 KDa |
| CCL21 | PEM0263 | Recombinant Mouse CCL21 | Mouse | 12.1 KDa |
| CCL3 (N-6His) | PEM0255 | Recombinant Mouse CCL3 (N-6His) | Mouse | 10.8 KDa |
| CCL24 | PEM0254 | Recombinant Mouse CCL24 | Mouse | 10.3 KDa |
| CCL2 | PEM0252 | Recombinant Mouse CCL2 | Mouse | 8.5 KDa |
| CCL1 | PEH2085 | Recombinant Human CCL1 | Human | 8.62 KDa |
| IL-8 (72AA) | PEH0482 | Recombinant Human IL-8 (72AA) | Human | 8.45 KDa |
| IL-8 (77AA) | PEH0481 | Recombinant Human IL-8 (77AA) | Human | 8.9 KDa |
| CXCL7 | PEH0478 | Recombinant Human CXCL7 | Human | 7.6 KDa |
| CXCL5 | PEH0477 | Recombinant Human CXCL5 | Human | 7.95 KDa |
| CXCL3 (N-6His) | PEH0475 | Recombinant Human CXCL3 (N-6His) | Human | 10.1 KDa |
| CXCL2 | PEH0474 | Recombinant Human CXCL2 | Human | 7.67 KDa |
| CXCL14 | PEH0471 | Recombinant Human CXCL14 | Human | 9.4 KDa |
| CXCL12 (72AA) | PEH0470 | Recombinant Human CXCL12 (72AA) | Human | 8.53 KDa |
| CXCL12 (68AA) | PEH0469 | Recombinant Human CXCL12 (68AA) | Human | 8 KDa |
| CXCL12(75AA) | PEH0468 | Recombinant Human CXCL12(75AA) | Human | 8.79 KDa |
| CXCL10 | PEH0467 | Recombinant Human CXCL10 | Human | 8.6 KDa |
| CCL8 | PEH0273 | Recombinant Human CCL8 | Human | 8.9 KDa |
| CCL5 | PEH0272 | Recombinant Human CCL5 | Human | 7.8 KDa |
| CCL3 | PEH0270 | Recombinant Human CCL3 | Human | 7.5 KDa |
| CCL28 | PEH0269 | Recombinant Human CCL28 | Human | 12.49 KDa |
| CCL27 | PEH0268 | Recombinant Human CCL27 | Human | 10.1 KDa |
| CCL26 (68AA) | PEH0267 | Recombinant Human CCL26 (68AA) | Human | 8.21 KDa |
| CCL26 (71AA) | PEH0266 | Recombinant Human CCL26 (71AA) | Human | 8.53 KDa |
| CCL23 | PEH0264 | Recombinant Human CCL23 | Human | 8.7 KDa |
| CCL18 (N-6His) | PEH0262 | Recombinant Human CCL18 (N-6His) | Human | 10.1 KDa |
| CCL11 | PEH0259 | Recombinant Human CCL11 | Human | 8.56 KDa |
| CCL2 | PEH0253 | Recombinant Human CCL2 | Human | 8.7 KDa |
验证数据
相关产品
参考文献
1. The chemokines and their receptors: characteristics and physiological functions. Guerreiro R, et al. Acta Med Port. 2011. [PMID: 22863506]
2. Chemokines and Bone. Gilchrist A. Handb Exp Pharmacol. 2020. [PMID: 32661663]
