细胞凋亡
细胞凋亡是一种受到严格调控的过程，可使细胞有序解体并被清除。与坏死性细胞死亡不同，凋亡调控机制精密，在机体发育、免疫功能维持以及组织稳态中发挥关键作用。正常细胞在受到各类内源性与外源性刺激时会发生凋亡，以此维持细胞存活与死亡之间的平衡。 凋亡细胞具有特征性表现：DNA 片段化、细胞与细胞膜空泡化，以及凋亡小体的形成 —— 凋亡过程产生的细胞碎片。磷脂酰丝氨酸等特异性细胞表面标志物，可将凋亡与坏死等其他细胞死亡形式区分开来。细胞凋亡的一个核心特点是：凋亡细胞被清除时不会引发组织炎症。吞噬细胞可有效吞噬清除凋亡细胞与凋亡小体，不会对组织微环境造成进一步损伤。
产品列表
| 类别 | 靶标 | 货号 | 产品名称 | 反应种属 | 应用 |
|---|---|---|---|---|---|
| Death Receptor Related | FADD | AMRe10792 | FADD (16T14) Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,FC,IP,IF-P |
| Death Receptor Related | Fas | AMRe21515 | Fas Rabbit Monoclonal Antibody | Human | WB,IHC,IF,ELISA |
| Death Receptor Related | ICAD | AMRe04085 | ICAD Rabbit Monoclonal Antibody | Human,Rat | WB |
| AMRe04127 | ICAD Rabbit Monoclonal Antibody | Human | WB,IP | ||
| AMRe12333 | ICAD (16K15) Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF | ||
| Death Receptor Related | Lamin A/C | AMRe02200 | Lamin A/C Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,IP |
| AMRe21305 | Lamin A/C Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA,IP | ||
| Death Receptor Related | PARP1 | AMRe01832 | Cleaved-PARP1 Rabbit Monoclonal Antibody | Human | WB |
| AMRe02401 | PARP1 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF | ||
| Death Receptor Related | ROCK1 | AMRe02547 | ROCK1 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| Death Receptor Related | ROCK2 | AMRe01447 | ROCK2 Rabbit Monoclonal Antibody | Human,Rat | WB,ICC/IF |
| Caspase Apoptosis Initiator | Caspase2 | AMRe04030 | Caspase-2 Rabbit Monoclonal Antibody | Human, Mouse, Rat | WB,IHC,ICC/IF,FC |
| Caspase Apoptosis Initiator | Caspase8 | AMRe07982 | Caspase-8 (3Q3) Rabbit Monoclonal Antibody | Human,Mouse,Rat,Pig,Chicken | WB,IHC,IF,ELISA |
| Caspase Apoptosis Initiator | Caspase9 | AMRe04045 | Caspase 9 Rabbit Monoclonal Antibody | Human,Mouse | WB,IP |
| Caspase Apoptosis Initiator | Caspase10 | AMRe01760 | Caspase 10 Rabbit Monoclonal Antibody | Human | WB,IHC,IP |
| AMRe83825 | proCaspase 10 Rabbit Monoclonal | Human,Mouse | WB,IHC,ICC/IF,ICC,FC,IP | ||
| Caspase Apoptosis Effector | Caspase3 | AMRe01762 | Cleaved-Caspase 3 p12 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF |
| AMRe01763 | Cleaved-Caspase 3 p17 Rabbit Monoclonal Antibody | Mouse,Human,Rat | WB | ||
| AMRe01567 | Caspase 3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IP | ||
| AMRe06553 | active + pro Caspase 3 (3L14) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IP | ||
| AMRe84828 | Cleaved-Caspase 3 p12 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC | ||
| AMRe85225 | Caspase 3 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IP | ||
| Caspase Apoptosis Effector | Caspase6 | AMRe21070 | Caspase-6 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| AMRe07974 | Caspase-6 (13P13) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA | ||
| Caspase Apoptosis Effector | Caspase7 | AMRe01764 | Caspase 7 Rabbit Monoclonal Antibody | Mouse,Rat | WB,ICC/IF,IP |
| Caspase Apoptosis Effector | Caspase1 | AMRe21189 | Caspase-1 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP |
| Caspase Apoptosis Effector | Caspase5 | AMRe83824 | Caspase 5 Rabbit Monoclonal | Human | WB,IHC,ICC/IF,ICC,IP |
| Other Caspase Proteins | Caspase 11 | AMRe01761 | Caspase 11 Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| AIF | AMRe06698 | AIF (11G15) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP | |
| AIFM1 | AMRe21174 | AIFM1 Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA | |
| Mitochondria Related | APAF1 | AMRe06987 | APAF1 (1L2) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IP |
| Mitochondria Related | ATF4 | AMRe07275 | ATF4 (16F19) Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,FC,IP |
| Mitochondria Related | Cytochrome C | AMRe01881 | Cytochrome C Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,IP |
| AMRe21457 | Cytochrome C Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA | ||
| Mitochondria Related | EndoG | AMRe01453 | ENDOGL1 Rabbit Monoclonal Antibody | Human | WB |
| AMRe84744 | ENDOGL1/ENGL Rabbit Monoclonal | Human | WB,IP | ||
| Mitochondria Related | SMAC | AMRe02612 | SMAC Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,IP |
| AMRe21157 | XIAP Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,ICC/IF,ELISA,IP | ||
| Stress & DNA Damage | Calpain 1 | AMRe07863 | Calpain 1 (19K17) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC |
| Stress & DNA Damage | DDIT3 | AMRe01568 | DDIT3 Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC |
| Stress & DNA Damage | JNK | AMRe03748 | JNK Rabbit Monoclonal Antibody | Human,Mouse,Rat,Hamster | WB,IP |
| AMRe12841 | JNK (19C18) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,ICC/IF,FC,IP | ||
| Stress & DNA Damage | p53 | AMRe02387 | p53 Rabbit Monoclonal Antibody | Human | WB,IHC,IF,IP,ELISA |
| AMRe15639 | p53 (15W6) Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,FC,IP | ||
| Bcl-2 Family | Bad | AMRe01709 | Bad Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| AMRe21496 | Bad Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP | ||
| Bcl-2 Family | Bcl2 | AMM03611 | Bcl2 (9A4) Mouse Monoclonal Antibody | Human,Rat,Mouse | WB |
| Bcl-2 Family | Bcl-XL | AMRe04056 | Bcl-XL Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,IP,ELISA |
| AMRe07516 | Bcl-XL (4B16) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC,IP | ||
| AMRe83686 | Bcl-XL Rabbit Monoclonal | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC,IP | ||
| Bcl-2 Family | Bid | AMRe21018 | BID Rabbit Monoclonal antibody | Human | WB,IHC,IF,IP,ELISA |
| AMRe07557 | Bid (6Y3) Rabbit Monoclonal Antibody | Human | WB,IHC,ICC/IF,FC,IP,IF-P | ||
| Bcl-2 Family | Bim | AMRe83736 | Bim Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC,IP |
| Bcl-2 Family | Bok | AMRe01733 | Bok Rabbit Monoclonal Antibody | Human,Rat | WB |
| AMRe85356 | Bok Rabbit Monoclonal Antibody | Human,Rat | WB | ||
| Bcl-2 Family | MCL1 | AMRe13712 | MCL1 (18O13) Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,FC |
| Bcl-2 Family | NOXA | AMRe02829 | NOXA Rabbit Monoclonal Antibody | Human | WB |
| Bcl-2 Family | PUMA | AMRe02498 | PUMA Rabbit Monoclonal Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| AMRe21276 | PUMA Rabbit Monoclonal antibody | Human,Mouse,Rat | WB,IHC,ICC/IF,ELISA,IP | ||
| AMRe83766 | PUMA Rabbit Monoclonal | Human,Mouse,Rat | WB,IHC,ICC/IF,ICC,FC | ||
| Bcl-2 Family | AKT | AMRe03759 | AKT Rabbit Monoclonal Antibody | Human,Mouse,Rat,Hamster | WB,IHC,ICC/IF,IP |
| AMRe21259 | Akt (pan) Rabbit Monoclonal antibody | Human,Mouse,Rat,Chicken,Goat | WB,IHC,IF,IP,ELISA,CHIP,Cut&Tag | ||
| Bcl-2 Family | ERK1/2 | AMRe21337 | ERK1/2 Rabbit Monoclonal antibody | Human,Mouse,Rat,Geese | WB,IHC,IF,IP,ELISA |
| Bcl-2 Family | NF-KB p65 | AMRe03785 | NF-KB p65 Rabbit Monoclonal Antibody | Human,Mouse | WB,IHC,ICC/IF,IP |
相关产品
参考文献
- Apoptosis: a review of programmed cell death. Elmore, S. Toxicol. Pathol. 2007. [PMID: 17562483]
- Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Bertheloot, D., et al. Cell Mol Immunol. 2021. [PMID: 33785842]
- Apoptosis. Fleisher TA. Ann Allergy Asthma Immunol. 1997. [PMID: 9087147]
- Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications. Mustafa M, et al. Cells. 2024. [PMID: 39594587]
