成脂分化标志物
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成脂分化是间充质干细胞(MSCs)分化为成熟脂肪细胞的过程,可分为白色脂肪形成(白色脂肪细胞)和棕色脂肪形成(棕色脂肪细胞)两个类型。整个过程分为两个阶段:定向分化阶段与终末分化阶段。在定向分化阶段,前脂肪细胞确定分化命运;在终末分化阶段,细胞形态与基因表达发生显著变化,最终形成具备储能功能的成熟脂肪细胞。乙酰辅酶A羧化酶(ACC)是脂肪酸合成与氧化通路中的关键酶,负责催化乙酰辅酶A羧化生成丙二酰辅酶A。





产品列表
靶标货号产品名称反应种属应用

乙酰辅酶A羧化酶

AMRe84227

乙酰辅酶A羧化酶 兔单克隆抗体

人

WB,IHC,ICC,IF

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参考文献

  • Loss of Mfn1 but not Mfn2 enhances adipogenesis. Mann J.P., et al.  PLoS One. 2024. [PMID: 39739772]
  • Distinct adipose progenitor cells emerging with age drive active adipogenesis. Wang G, et al. Science. 2025. [PMID: 40273250]
  • Hawley, S.A. et al. (1996) J. Biol. Chem. 271, 27879-27887.
  • Longitudinal expression profiles of key markers during stages of adipogenic differentiation of 3T3-L1 cells using the PPARG agonist rosiglitazone. Schouwink M. et al. Biochem Biophys Res Commun. 2025. [PMID: 40378617]
  • A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change. Turn et al. Genes Dev. 2025. [PMID: 40675820]
  • Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview. Audano M. et al. Cell Mol Life Sci. 2022. [PMID: 35184223]
  • Establishing Immortalized Brown and White Preadipocyte Cell Lines from Young and Aged Mice. Wu X. et al. Curr Protoc. 2024. [PMID: 39670655]
  • Fast Adipogenesis Tracking System (FATS)-a robust, high-throughput, automation-ready adipogenesis quantification technique. Yuan C, et al. Stem Cell Res Ther. 2019. [PMID: 30670100]
  • Transcriptional control of adipocyte formation. Farmer SR. Cell Metab. 2006. [PMID: 17011499]
  • ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus. Castle JC, et al.  PLoS One. 2009. [PMID: 19190759]
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