生命科学科研大百科

ER stress-induced autophagy is the core mechanism by which cells respond to protein homeostasis imbalances.

Chaperone-mediated autophagy (CMA) is a process triggering the lysosomal-mediated degradation of specific protein targets. CMA is induced by a variety of stresses, including starvation, genotoxic insults, oxidative stress, and hypoxia.

ATM (Ataxia Telangiectasia Mutated) is a serine/threonine protein kinase best known for its role in the DNA damage signaling cascade in response to DNA double-strand breaks (DSBs).

Autophagosome markers are molecular tools used to identify, localize autophagosomes and evaluate autophagic activity, serving as core components in studying autophagic mechanisms and analyzing autophagic abnormalities related to diseases.

ATP-dependent chromatin remodeling complexes play an essential role in the regulation of various nuclear processes, such as gene expression, DNA replication, and repair. The SWI/SNF chromatin remodeling complex consists of more than 10 subunits with a single molecule of the ATPase catalytic subunit BRM or BRG1, but not both. The activities of these two subunits drive the disruption of histone-DNA contacts that lead to changes in accessibility of crucial regulatory elements within chromatin.

Autophagy vesicle elongation is a crucial phase in the autophagy process, during which Atg12 conjugation plays a vital role. In this process, Atg12 is covalently attached to Atg5 through a ubiquitin-like conjugation system to form the Atg12-Atg5 complex.

Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure.

α-thalassemia/mental retardation X-linked (ATRX) is a transcriptional regulator and helicase that belongs to the SNF2 family of chromatin remodeling proteins. Together with its binding partner death-associated protein 6 (Daxx), ATRX acts as histone chaperone to deposit histone variant H3.3 at repetitive DNA sequences such as telomeric, pericentric, and ribosomal gene repeats.

Autophagy Vesicle Elongation is a crucial phase in the autophagy process, primarily involving the conjugation of LC3 protein (LC3 Conjugation) and the expansion and closure of the autophagosome membrane.

Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress.